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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC7
All Species:
13.64
Human Site:
S181
Identified Species:
37.5
UniProt:
O00311
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00311
NP_001127891.1
574
63888
S181
V
H
R
D
V
K
P
S
N
F
L
Y
N
R
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097186
574
63766
S181
V
H
R
D
V
K
P
S
N
F
L
Y
N
R
R
Dog
Lupus familis
XP_537080
756
83548
S362
V
H
R
D
V
K
P
S
N
F
L
F
N
R
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0H0
564
62734
D171
Q
F
G
I
V
H
R
D
V
K
P
S
N
F
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521163
410
45484
K24
N
V
F
K
I
E
D
K
I
G
E
G
T
F
S
Chicken
Gallus gallus
XP_422347
564
62394
S175
V
H
R
D
V
K
P
S
N
F
L
Y
N
R
R
Frog
Xenopus laevis
NP_001081878
483
53563
D97
K
Y
C
F
R
N
K
D
H
V
V
I
V
M
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785538
591
65818
G201
I
H
R
D
V
K
P
G
N
F
L
Y
N
R
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06243
507
58302
L120
R
D
Q
V
I
A
V
L
P
Y
Y
P
H
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.8
68.9
N.A.
78
N.A.
N.A.
61.3
67.2
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
Protein Similarity:
100
N.A.
97.7
71.5
N.A.
84.8
N.A.
N.A.
65.6
78.7
66.9
N.A.
N.A.
N.A.
N.A.
N.A.
54.4
P-Site Identity:
100
N.A.
100
93.3
N.A.
13.3
N.A.
N.A.
0
100
0
N.A.
N.A.
N.A.
N.A.
N.A.
80
P-Site Similarity:
100
N.A.
100
100
N.A.
13.3
N.A.
N.A.
13.3
100
20
N.A.
N.A.
N.A.
N.A.
N.A.
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
0
56
0
0
12
23
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
12
0
0
0
0
12
0
0
12
12
% E
% Phe:
0
12
12
12
0
0
0
0
0
56
0
12
0
23
0
% F
% Gly:
0
0
12
0
0
0
0
12
0
12
0
12
0
0
0
% G
% His:
0
56
0
0
0
12
0
0
12
0
0
0
12
0
12
% H
% Ile:
12
0
0
12
23
0
0
0
12
0
0
12
0
0
0
% I
% Lys:
12
0
0
12
0
56
12
12
0
12
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
12
0
0
56
0
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% M
% Asn:
12
0
0
0
0
12
0
0
56
0
0
0
67
0
0
% N
% Pro:
0
0
0
0
0
0
56
0
12
0
12
12
0
0
12
% P
% Gln:
12
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
12
0
56
0
12
0
12
0
0
0
0
0
0
56
45
% R
% Ser:
0
0
0
0
0
0
0
45
0
0
0
12
0
0
12
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% T
% Val:
45
12
0
12
67
0
12
0
12
12
12
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
12
0
0
0
0
0
0
0
12
12
45
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _